Popular Rom-Com "My Friend's Little Sister Has It In for Me" Set for Fall 2025 Anime Season Premiere on October 4th

As a highly anticipated title for the Fall 2025 anime season, the immensely popular romantic comedy "My Friend's Little Sister Has It In for Me" (GA Bunko original) has officially announced its broadcast premiere on Saturday, October 4th. Alongside this announcement, a new key visual and the main promotional video (PV) have been released, offering a glimpse into the series' world and the charm of its main characters.

The series is a chaotic romantic comedy depicting the daily life of protagonist Akiteru Ōboshi, who is constantly "annoyingly entangled" by his best friend's little sister, Iroha Kohinata. Supported by many fans as an "annoying but lovable character," anticipation for this long-awaited anime adaptation is at an all-time high. The broadcast schedule includes TV Asahi's NUMAnimation block starting October 4th (Saturday) at 25:30 (effectively Sunday at 1:30 AM JST), BS11 on October 5th (Sunday) at 24:30 (effectively Monday at 0:30 AM JST), and AT-X on October 6th (Monday) at 22:00 JST, making it viewable across multiple channels.

Particularly generating buzz is the announcement of the theme song artists. The opening theme, "Uza-Kawaii Nante Warukunai!" (What's Wrong with Being Annoyingly Cute!), will be performed by popular VTuber Akami Karubi. She expressed her overwhelming joy on X (formerly Twitter), exclaiming, "An anime opening theme!?!?! My dream has come true, this is amazing ✨✨✨✨🥲." Fans have poured in with congratulatory messages such as "Karubi-hime finally did it!" and "So touching." The ending theme, "Hoshi no Kodō" (Star's Pulse), will be performed by Kohana Lam. The main PV also offered the first listen of both songs, quickly building anticipation for the music that will color the series.

The main cast features Haruki Ishiya as the protagonist Akiteru Ōboshi, and Sayumi Suzushiro as the heroine Iroha Kohinata. Haruki Ishiya commented in his own post, "We're showing you just a glimpse of the unique and vibrant characters!" Attention is focused on how Suzushiro's high-spirited Iroha will playfully disrupt Ishiya's Akiteru, and their dynamic interplay.

For this series, which has long been anticipated for an anime adaptation, social media is abuzz with passionate fan comments, such as "It's been a long wait since the anime adaptation was announced, but it's finally here!" and "From the title alone, 'annoyingly cute' is guaranteed!" This autumn, the "Uza-Kawa" (annoyingly cute) phenomenon looks set to sweep across Japan.

The context

"My Friend's Little Sister Has It In for Me" (友人の妹が俺にだけウザい, Tomodachi no Imōto ga Ore ni dake Uzai), often shortened to "Uzaimo," is a popular Japanese light novel series published under GA Bunko. Light novels are a common source material for anime adaptations, particularly within the romantic comedy (rom-com) genre, which often features lighthearted, character-driven stories centered on humor and budding relationships. The term "Uza-Kawa" (ウザかわ) is a Japanese portmanteau combining "uzai" (annoying/bothersome) and "kawaii" (cute), describing a character who is initially perceived as annoying but is ultimately endearing and lovable.

TV Asahi's "NUMAnimation" block is a late-night anime programming slot known for airing popular and sometimes experimental anime series, often targeting a broader audience beyond traditional daytime children's programming. The involvement of a VTuber like Akami Karubi for the opening theme reflects a growing trend of virtual talents crossing over into mainstream entertainment, particularly within the anime and music industries.